Creatinine is a waste product, produced in muscle because of the normal breakdown of creatine, a substance involved in the production of energy for muscle contraction. Creatinine is produced at a relatively constant rate and filtered from the blood by the kidneys. It is excreted from the body through urine.
Creatinine levels in the blood can serve as an important indicator of kidney function. If the kidneys are not working properly, they may have trouble filtering creatinine from the blood, causing elevated levels in the bloodstream. This is why creatinine is commonly used as a marker to assess kidney health and diagnose conditions such as kidney disease or impaired kidney function.
Doctors often measure creatinine levels in the blood to estimate the glomerular filtration rate (eGFR), which is a measure of how well the kidneys are filtering waste from the blood. A decrease in EGFR and an increase in creatinine levels can be a sign of kidney failure or kidney disease. Additionally, creatinine clearance tests, which involve collecting urine samples over a 24-hour period, can provide more accurate information about kidney function.
It's worth noting that factors such as age, gender, muscle mass, and certain medications can also affect creatinine levels. If there are concerns about kidney function or overall health, it is essential to consult a healthcare professional for proper diagnosis and guidance.
When to worry about creatinine levels
Elevated creatinine levels: If your blood test results show persistently high levels of creatinine, this may indicate decreased kidney function. Elevated creatinine levels can be a sign of acute kidney injury, chronic kidney disease, or other underlying health problems.
Changes in creatinine levels:
If there is a sudden and significant increase in creatinine levels, this may indicate acute kidney injury, which may be caused by factors such as dehydration, infection, medications, or other medical conditions. Is. If you notice a sudden change in creatinine level, immediate medical attention is necessary.
Decreased kidney function:
A decrease in the estimated glomerular filtration rate (eGFR), calculated based on creatinine levels and other factors, may suggest decreased kidney function. An eGFR of less than 60 mL/min/1.73 m² for three months or more may indicate chronic kidney disease. Your doctor will evaluate your kidney function and determine the appropriate management.
Diabetes and high blood pressure:
People with diabetes and high blood pressure are at increased risk of kidney disease. Monitoring of creatinine levels is important in these individuals, as kidney damage may occur gradually without noticeable symptoms.
Drug effects:
Some drugs, such as certain antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), can affect kidney function and increase creatinine levels. If you are taking these medicines, your doctor may monitor your kidney function regularly.
Advanced age:
As people age, kidney function naturally declines. Creatinine levels may be slightly elevated in older adults despite relatively normal kidney function. However, significant increases in creatinine levels should be investigated.
Dehydration:
Dehydration can temporarily increase creatinine levels. Staying hydrated is essential, especially before a blood test, to ensure accurate results.
If you are concerned about your creatinine level, it is best to consult a healthcare professional. They can review your medical history, perform necessary tests, and provide guidance based on your situation. Remember that creatinine levels are only one part of the overall picture of kidney health, and your doctor will consider a number of factors to accurately assess your kidney function.
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